Table 1.

Relative risk.

Reproductive toxicity end point	Relative risk (95% CI)	(+) Cutoff:C. elegans assay	Time point
MGR_Rat_Fertility	4.05 (0.35, 46.60)	1.80	24 hr
MGR_Rat_LitterSize	6.82 (0.82, 56.76)	1.64	24 hr
MGR_Rat_Ovary	9.69 (1.11, 84.53)	1.71	65 hr
MGR_rat_ReproductiveOutcome	8.08 (1.11, 58.93)	1.43	24 hr
MGR_rat_ReproductivePerformance	9.45 (1.19, 74.85)	1.80	24 hr
MGR_Rat_ViabilityPND4	2.56 (1.49, 2.39)	1.64	24 hr
mgLEL (any)	2.15 (1.75, 2.64)	1.69	65 hr
Abbreviations: MGR, multigenerational; PND4, postnatal day 4. For each reproductive toxicity end point, relative risk was calculated by iteratively increasing the cutoff value (log fold ratio over DMSO control) for a positive result in theC. elegans assay at each time point. Maximum relative risks and 95% CIs are shown for cutoff values within a range shown to maximize the predictive value of the assay.