Table 1.
Gene enrichment analysis report. A MetaCore analysis of genes that significantly change in their TGF-β regulation (false discovery rate < 0.05 and fold change > 2) between the parental cells and Arkadia C937A-expressing cells. They are ordered with respect to p value
| Networks | Total1 | p value | No. genes in data |
Genes from active data2 |
|---|---|---|---|---|
|
Cell adhesion and
cell–matrix interaction |
213 | 7.096 × 10−4 | 8 | TGFB1; ADAM-TS14; Collagen V; MMP-8; COL5A1; COL1A2; LAMC2; SPOCK1 |
|
Proteolysis, ECM
remodeling |
85 | 1.07 × 10−3 | 5 | LRP1; ADAM-TS14; PAI1/Serpine1; MMP-8; SPOCK1 |
|
Proteolysis, connective tissue degradation |
119 | 4.69 × 10−3 | 5 | LRP1; ADAM-TS14; PAI1/Serpine1; MMP-8; SPOCK1 |
| Development, EMT | 232 | 5.31 × 10−3 | 7 | AP-1; KRT14; PAI1/Serpine1; Lysyl Oxidase; SNAIL1; PDGF-B; COL1A2 |
|
Cytoskeleton and
intermediate filaments |
81 | 6.49 × 10−3 | 4 | PPL (periplakin); KRT14; KRT17; KRT7 |
|
Cardiac
development, role of NADPH oxidase and ROS |
133 | 7.47 × 10−3 | 5 | MYH15; SNAIL1; NCF2; Gli-2; ID1 |
|
Reproduction,
gonadotrophin regulation |
199 | 9.82 × 10−3 | 6 | G-specific class A orphan/other GPCRs; AP-1; FosB; JunB; VIPR1 |
| Proliferation | 221 | 1.59x 10−2 | 6 | AP-1; G(i)-specific amine GPCRs; CSF1R; VIPR1; HTR1D; TACSTD2 |
|
Cardiac
development: TGF-β and BMP signaling |
117 | 2.26 × 10−2 | 4 | MYH15; SNAIL1; Gli-2; ID1 |
|
Development,
neurogenesis, synaptogenesis |
180 | 2.49 × 10−2 | 5 | LRP1; Syntrophin B; KIF17; Synaptotagmin II; Synaptotagmin |
1
Total refers to the number of MetaCore entries associated with a particular network.
2
In most cases these are individual genes. In some cases however multiple members of one family have been mapped to the same MetaCore database entry for example, Lysyl oxidase or AP-1.