Fig 2. Recurrent somatic mutations in FOXA1 and MED12.

Mutations detected by exome sequencing are depicted (red), as are variants from non-overlapping transcriptome sequencing data (blue). (A) Structural analysis of mutations in FOXA1. Mutated residues are mapped to the structure of the HNF3γ fork-head domain from coordinate file 1VTN.pdb (www.pdb.org)²⁴ and highlighted in red. FH, Fork-head domain. (B) Recurrent MED12 mutations in prostate cancer (red, blue) are distinct from those reported in uterine leiomyeoma (shown in black)²⁸. Domains of MED12 are denoted as in Zhou et al.²⁵. Multispecies conservation of the mutated sites is shown below the mutation.