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. 2012 Jun 12;23(7):1731–1741. doi: 10.1093/cercor/bhs168

Figure 8.

Figure 8.

Depolarization-induced endocannabinoid release boosts bAP-induced calcium transients. (A) Alexa 594 and Oregon Green filled layer 2/3 PN. (B) Dendritic calcium transients before and 60 s after AP train (40 Hz for 2 s). Scale bars: 250 ms, 50% ΔF/F. (C) Group time course of calcium transient peak amplitude before and after AP train (arrow; n= 13). (D) Layer 2/3 PN. (E) Dendritic calcium transients before and 60 s after AP train in the presence of the CB1 receptor antagonist AM251 (5 μM). Scale bars same as (B). (F) Group time course of calcium transient peak amplitude in the presence of AM251 (n= 10). (G) Evoked inhibitory postsynaptic currents (eIPSCs), recorded from the soma of a layer 2/3 PN, before (gray) and 60 s after (black) AP train (same as in B). Scale bars: 10 ms, 100 pA. (H) Group time course of eIPSCs before and after AP train (arrow; n= 21). *P < 0.05.