Table 1.

Endogenous metabolite variations induced by BPA exposure (25 µg) in PND2 pups and in serum, liver, and brain of PND21 mice compared with controls.

Metabolites	1H NMR chemical shifts δ (ppm)	PND2	PND21
		Whole body	Serum	Liver	Brain
Lipidsa	0.86 (m); 0.90 (m); 1.26 (m); 1.30 (m)		–
Lactate	1.33 (d); 4.11 (q)	+	–	–
Glucose	3.54 (m); 3.66 (m); 3.70 (m); 3.74 (m); 3.78 (m); 3.82 (m); 3.86 (m); 3.90 (m)	+	+	–
Taurine	3.26 (t); 3.42 (t)		+	+
Cholinesb	3.20 (s); 3.22 (s); 3.23 (s)	+	+	–	–
Creatine	3.03 (s); 3.93 (s)	+
Glutamate	2.08 (m); 2.34 (m)			+	–
Glutamine	2.14 (m); 2.46 (m)				+
Glycine	3.55 (s)	+			+
Valine, leucine, isoleucine	0.94 (d); 0.96 (d); 1.0 (d); 1.01 (d); 1.05 (d)	–
Lysine	1.72 (m); 2.98 (m)	–
Glutathione	2.17 (m); 2.56 (m); 2.94 (m)			+
Glycogen	5.42 (m)			–
Aspartic acid	2.65 (dd); 2.80 (dd)				+
GABA	1.90 (q); 2.27 (t); 3.01 (t)				–
Abbreviations: +, significantly increased concentration; –, significantly decreased concentration; GABA, γ-aminobutyric acid. Chemical shifts (ppm) are relative to TMSP (1H, δ). Multiplicity of signals is indicated in parentheses: d, doublet; dd, doublet of doublet; m, multiplet; q, quadruplet; s, singlet; t, triplet. a Low-density lipoprotein and very-low-density lipoprotein. bPhosphatidylcholine and glycerophosphocholine.