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. 2013 Feb 20;121(5):613–618. doi: 10.1289/ehp.1206066

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Effects of TCDD on AChE activity via direct inhibition of the enzyme (A) and via the AhR-dependent pathway (B). (A) AChE activity in cell lysate of SK‑N‑SH incubated with TCDD (10^–11 to 10^–9 M), 2 × 10^–5 M BW284c51 (AChE inhibitor used as the positive control), or with 0.1% DMSO (control) for 1 hr. (B) AChE activity in cultured SK‑N‑SH cells incubated with 10^–6 M CH223191 (AhR inhibitor) or 0.1% DMSO for 3 hr and then incubated with 10^–9 M TCDD or 0.01% DMSO for 24 hr. See “Materials and Methods” for additional details. Values were calculated as a percentage of control and are expressed as mean ± SE (n = 4); each independent sample was tested in triplicate. *p < 0.05 compared with control by one-way ANOVA with Bonferroni test. ^#p < 0.05 compared with TCDD alone by one-way ANOVA with Bonferroni test.