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. 2013 Feb 20;121(5):613–618. doi: 10.1289/ehp.1206066

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Putative DREs in the human AChE promoter and their response to TCDD exposure. (A) Putative DRE consensus sequences in the pAChE-Luc construct (full-length; top), pAChE-T-Luc (truncated; middle), and pAChE-M-Luc (mutant; bottom). (B) The three constructs were transiently transfected into cultured SK‑N‑SH cells 1 day before 24 hr incubation with TCDD (10^–10 to 10^–9 M) or 0.1% DMSO (control); luciferase assays were then performed to determine the promoter activity. See “Materials and Methods” for additional details. Values were calculated as a percentage of control and are expressed as mean ± SE (n = 3); each independent sample was tested in triplicate. *p < 0.05 compared with control by one-way ANOVA with Bonferroni test. ^#p < 0.05 compared with pAChE-Luc transfected cells by two-way ANOVA with Bonferroni test.