Table 2.
Electrophysiological characteristics of GPi and GPe neurons in HD and PD with subjects at rest. Values are mean +/− standard deviation of mean
| GPi | GPe | |||||
|---|---|---|---|---|---|---|
| HD | PD | p-value | HD | PD | p-value | |
| # of neurons | 24 | 132 | 9 | 50 | ||
| Mean firing rate | 58.14 +/− 19.1 | 94.7 +/− 23.7 | <.001* | 72.9 +/− 15.18 | 57.46 +/− 21.72 | .024* |
| Burst index | 4.79 +/− 1.68 | 2.35 +/− 0.98 | <.001* | 2.51 +/− 0.71 | 2.84 +/− 1.35 | NS |
| Proportion of spikes in bursts | 0.094 +/− 0.105 | 0.045 +/− 0.063 | .001* | 0.041 +/− 0.044 | 0.119 +/− 0.101 | 0.019* |
| L-statistic | 5.75 +/− 0.85 | 4.82 +/− 0.85 | <.001* | 4.89 +/− 0.60 | 5.34 +/− 1.10 | NS |
| Proportion of cells with significant oscillations 3–35 Hz | 1/24 | 27/132 | 0.006* (chi-square) | 0 | 0 | NS |
denotes statistically significant difference between HD and PD by Mann-Whitney test (unpaired) or chi-square test.