Adaptive walks |
Sequences of beneficial mutations |
Altruistic |
An action directed towards another individual which results in a cost to the helper and a benefit to the helped |
Angiogenesis |
The physiological recruit of new blood vessels |
Compensatory mutations |
Mutations which offset the negative fitness effects imposed by another mutation |
Cooperative |
An action which benefits both the helper and any helped |
Demographic features |
Characteristic features of a population |
Direct fitness |
An individual's own genetic contribution to the next generation |
Epidermal growth factor receptors |
Surface growth factor receptors |
Fitness landscape |
A multidimensional space where an artificial landscape comprised peaks and valleys represents a genotype or phenotype fitness value |
Hallmark behaviours |
Common traits of cancer cells |
Hypoxic |
Oxygen depleted environment |
Inclusive fitness |
The sum of an individual's direct and indirect fitness |
Indirect fitness |
The genetic contribution to the next generation gained from the reproduction of relatives |
Kin member |
Genetically related individual |
Metastatic (metastasis) |
Secondary tumours caused by the migration of cells from the primary tumour to other tissues within the body |
Mutualism |
Ecological relationship beneficial to both partners |
Neoplasm |
An abnormal tissue mass |
Phenotype |
Observable characteristics of an individual resulting from the interaction of its genotype with the environment |
Reversion |
Back mutation of a point mutation to its ancestral state |
Relatedness |
The level of consanguinity between two given individuals |
Selection gradient |
The slope of a regression of fitness on trait value |
Somatic cells |
Cells which make up the tissues of the body (i.e. not the germ cells) |
Stromal |
The supporting tissue of an organ |
Tyrosine kinase inhibitor (TKI) |
A drug that interferes with cell communication and growth and may prevent tumour growth |