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. 2013 Jan 3;6(3):535–548. doi: 10.1111/eva.12041
Adaptive walks Sequences of beneficial mutations
Altruistic An action directed towards another individual which results in a cost to the helper and a benefit to the helped
Angiogenesis The physiological recruit of new blood vessels
Compensatory mutations Mutations which offset the negative fitness effects imposed by another mutation
Cooperative An action which benefits both the helper and any helped
Demographic features Characteristic features of a population
Direct fitness An individual's own genetic contribution to the next generation
Epidermal growth factor receptors Surface growth factor receptors
Fitness landscape A multidimensional space where an artificial landscape comprised peaks and valleys represents a genotype or phenotype fitness value
Hallmark behaviours Common traits of cancer cells
Hypoxic Oxygen depleted environment
Inclusive fitness The sum of an individual's direct and indirect fitness
Indirect fitness The genetic contribution to the next generation gained from the reproduction of relatives
Kin member Genetically related individual
Metastatic (metastasis) Secondary tumours caused by the migration of cells from the primary tumour to other tissues within the body
Mutualism Ecological relationship beneficial to both partners
Neoplasm An abnormal tissue mass
Phenotype Observable characteristics of an individual resulting from the interaction of its genotype with the environment
Reversion Back mutation of a point mutation to its ancestral state
Relatedness The level of consanguinity between two given individuals
Selection gradient The slope of a regression of fitness on trait value
Somatic cells Cells which make up the tissues of the body (i.e. not the germ cells)
Stromal The supporting tissue of an organ
Tyrosine kinase inhibitor (TKI) A drug that interferes with cell communication and growth and may prevent tumour growth