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. Author manuscript; available in PMC: 2013 Oct 25.
Published in final edited form as: Cell. 2013 Apr 25;153(3):601–613. doi: 10.1016/j.cell.2013.03.028

Figure 3. VDR and SMAD3 Cistromes in Hepatic Stellate Cells.

Figure 3

(A) and (E) Pie charts illustrating genomic locations of VDR and SMAD3 binding sites in treated LX-2 cells (calcipotriol (100nM) and TGFβ1 (1ng/ml) for 4 hours following 16 hours calcipotriol (100nM) pretreatment, FDR<0.0001). Promoter regions, < 2kb from TSS; intergenic regions, not promoter, intron or exon. (B) and (F) Representative ChIP-Seq reads for VDR and SMAD3 aligned to the CYP24A1 and ID1 genes, respectively. (C) and (G) Gene ontology (GO) classification of genes annotated with VDR and SMAD3 binding sites. (D) and (H) De novo motif analysis performed on sequences located within 100bp of VDR and SMAD3 peaks (FDR<0.0001). See also Fig. S3 & S4.