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. Author manuscript; available in PMC: 2013 Jun 5.
Published in final edited form as: Biochemistry. 2012 Mar 9;51(11):2331–2347. doi: 10.1021/bi201657k

Figure 1.

Figure 1

Concentration dependent UV thermal denaturation profile of HIV TAR RNA with neomycin dimer DPA52. UV thermal denaturation data of HIV-1 TAR RNA at (A) 0, (B) 4 μM (4 mol. eq.) of DPA52. (E) The plot shows the change in thermal stabilization (ΔTm) as a function of molar equivalents of DPA52. Buffer conditions: 100 mM KCl, 10 mM SC, 0.5 mM EDTA, pH 6.8. [HIV TAR RNA] = 1 μM/strand. The heating rate was 0.3 °C.