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Bar graph showing the comparison of binding constants derived from Scatchard analysis of the FID titrations (ethidium bromide as in intercalator) (left) and UV thermal denaturation profile of neomycin dimers with HIV TAR RNA (right). Buffer conditions: 100 mM KCl, 10 mM SC, 0.5 mM EDTA, pH 6.8. For FID titration, [HIV TAR RNA] = 200 nM/strand. For UV thermal denaturation experiment, [HIV TAR RNA] = 1 μM/strand. [Neomycin dimer] = 1 μM. [Neomycin] = 1 μM.
