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Representative table of binding constants derived from Scatchard analysis of the FID assay (ethidium bromide as in intercalator) between neomycin dimer and HIV TAR RNA. Buffer conditions: 100 mM KCl, 10 mM SC, 0.5 mM EDTA, pH 6.8. HIV TAR RNA = 200 nM/strand. [EtBr] = 5 μM.
| Neomycin Dimer | Linker Length | K (M−1) |
|---|---|---|
| DPA51 | 7 | 1.17×108 |
| DPA52 | 7 | 7.08×107 |
| DPA65 | 7 | 1.39×108 |
| DPA53 | 8 | 1.46×108 |
| DPA54 | 8 | 2.61×107 |
| DPA55 | 10 | 1.06×107 |
| DPA56 | 10 | 6.60×107 |
| DPA58 | 16 | 7.58×106 |
| DPA60 | 20 | 2.53×107 |
| Neomycin | NA | - |
