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. Author manuscript; available in PMC: 2013 Jun 5.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jun 21;21(16):4788–4792. doi: 10.1016/j.bmcl.2011.06.058

Scheme 2.

Scheme 2

Reagents and conditions: (a) (Boc)2O, DMF, H2O, Et3N, 60 C, 5 h, 60%. (b) TPS-Cl, pyridine, r.t., 40 h, 50%. (c) NaN3, DMF/H2O (10/1), 12h, 90 °C, 90%. (d) Toluene, CuI, DIPEA, 90 °C, 18 h, 85–92%. (e) 4 M HCl/dioxane, r.t., 5 min, 76–95%.