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. Author manuscript; available in PMC: 2013 Jun 5.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jun 21;21(16):4788–4792. doi: 10.1016/j.bmcl.2011.06.058

Table 1.

Table of UV thermal denaturation of ligand/HIV TAR RNA complexes at rdd = 1 and ΔTm. Buffer conditions: 100 mM KCl, 10 mM SC, 0.5 mM EDTA, pH 6.8. HIV TAR RNA = 1 μM/strand. Neomycin dimer = 1 μM. Neomycin = 1 μM.

Neomycin dimer Structure of the linker (-x-, from Scheme 1 and Scheme 2) Tm ΔTm
HIV-1 TAR RNA NA 68.9 NA
DPA 51 -O- 79.1 10.2
DPA 52 -CH2- 78.2 9.3
DPA 65 graphic file with name nihms306996t1.jpg 78.2 9.3
DPA 53 graphic file with name nihms306996t2.jpg 78.5 9.6
DPA 54 -CH2CH2- 77.1 8.2
DPA 55 graphic file with name nihms306996t3.jpg 76.4 7.6
DPA 56 graphic file with name nihms306996t4.jpg 74.9 6.1
DPA 58 graphic file with name nihms306996t5.jpg 74.3 5.4
DPA 60 graphic file with name nihms306996t6.jpg 72.1 3.3
Neomycin NA 69.1 0.2