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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jan 17;1833(5):1222–1234. doi: 10.1016/j.bbamcr.2013.01.007

Figure 8. Blocking the androgen/AR signaling increased the self-renewal of BM-MSCs in WT mice, but not in ARKO mice.

Figure 8

CFU-f test results of primary BM-MSCs of (A) WT and (B) ARKO mice in the presence of EtOH (vehicle) or 1μM HF. (C) pEGFR and EGFR expressions in C3H10T1/2 upon HF treatment (left panel) and primary WT BM-MSCs treated with ASC-J9® (right panel). (D) Western blot analysis results of pErk1/2 and Erk1/2 levels in C3H10T1/2 cells that were treated with vehicle or 1μM HF. (E, F) CFU-f test results of BM-MSCs that were treated with DMSO (vehicle) or 5μM ASC-J9®. (G) CFU-f test results of WT BM-MSCs that were infected with lentivirus packed with either scramble or AR-siRNA, **, p-value < 0.01, ***, p-value < 0.001, when compared to the control.