Table 1.

Studies providing evidence for or against a particular role of the uncinate fasciculus in various psychiatric disorders

	Evidence type	Summary of findings
Anxiety	DTI (Han et al., 2008; Kim and Whalen, 2009; Phan et al., 2009; Liao et al., 2011; Tröstl et al., 2011; Westlye et al., 2011; Baur et al., 2012; Hettema et al., 2012)	Findings are mixed. The uncinate fasciculus appears to play either a small role, or no role, in this disorder.
Schizophrenia	DTI (Burns et al., 2003; Kubicki et al., 2005; McIntosh et al., 2008; Price et al., 2008; Kawashima et al., 2009; Voineskos et al., 2010; Kitis et al., 2012; reviewed by Kubicki et al., 2007).	Findings are mixed. The uncinate fasciculus appears to play either a small role, or no role, in this disorder.
Psychopathy	DTI (Craig et al., 2009; Motzkin et al., 2011; Sundram et al., 2012).	All DTI studies reported reduced fractional anisotropy values in the right uncinate fasciculus.
	Volumetric MRI (Raine et al., 2000; Yang et al., 2009,Gregory et al., 2012).	Volumetric studies show bilateral volume losses in regions connected by uncinate fasciculus.