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. 2013 Jun;10(2):170–176. doi: 10.1089/zeb.2012.0816

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 4. — Adult Tg(−1.2ins:CDK4^R24C)^VU508 fish have increased β-cell mass and improved glucose tolerance. (A, B) Images of insulin positive islets in adult Tg(−1.2ins:CDK4^R24C; LR)^VU508 (B) and nontransgenic siblings (A), scale bars indicate 20 μm. (C) β-Cell area relative to total pancreas area, 10 control and 8 Tg(−1.2ins:CDK4^R24C; LR)^VU508 fish were analyzed, **p<0.001. (D) glucose clearance in Tg(−1.2ins:CDK4^R24C)^VU508 and nontransgenic siblings. Glucose was injected intraperiotneally at 0.5 mg glucose/g body weight and blood glucose levels determined 30 and 180 min after injection. 10–14 fish per time point for each group.