Table 4.
—Mixed-Effects Model-Generated Parameter Estimates for SGRQ Change Scores Resulting From Change in Anchor Scores
| Associations | Domain | Symptoms | Activity | Impact | Total |
| Cross-sectional | FEV1, mL | −0.014 ± 0.004 (.002) | −0.016 ± 0.004 (< .0001) | −0.015 ± 0.004 (.0009) | −0.015 ± 0.004 (.0001) |
| FEV1% | −0.46 ± 0.13 (.0009) | −0.48 ± 0.11 (< .0001) | −0.39 ± 0.13 (.003) | −0.42 ± 0.11 (.0002) | |
| Dlco, mL/min/mm Hg | −1.11 ± 0.45 (.02) | −1.72 ± 0.40 (< .0001) | −0.84 ± 0.58 (.21) | −1.15 ± 0.38 (.005) | |
| Dlco % | −0.30 ± 0.11 (.01) | −0.42 ± 0.10 (< .0001) | −0.20 ± 0.11 (.08) | −0.29 ± 0.09 (.004) | |
| 6MWD, m | −0.03 ± 0.02 (.12) | −0.07 ± 0.02 (.0002) | −0.04 ± 0.02 (.03) | −0.05 ± 0.02 (.004) | |
| Log(VEGF-D) | 4.14 ± 2.16 (.06) | 5.95 ± 2.22 (.009) | 3.45 ± 2.17 (.12) | 4.34 ± 1.95 (.03) | |
| Longitudinal | FEV1, mL | −0.018 ± 0.007 (.02) | −0.020 ± 0.005 (< .0001) | −0.021 ± 0.006 (.0007) | −0.020 ± 0.005 (< .0001) |
| 0.583 | 0.744 | 0.714 | 0.750 | ||
| FEV1% | −0.49 ± 0.22 (.03) | −0.56 ± 0.14 (< .0001) | −0.61 ± 0.18 (.001) | −0.57 ± 0.14 (.0003) | |
| 0.531 | 0.759 | 0.744 | 0.776 | ||
| Dlco, mL/min/mm Hg | −0.23 ± 0.75 (.76) | −0.42 ± 0.56 (.47) | −0.03 ± 0.82 (.97) | −0.28 ± 0.53 (.60) | |
| 0.580 | 0.788 | 0.784 | 0.797 | ||
| Dlco % | −0.06 ± 0.18 (.73) | −0.10 ± 0.14 (.49) | −0.05 ± 0.15 (.76) | −0.09 ± 0.12 (.47) | |
| 0.580 | 0.798 | 0.783 | 0.803 | ||
| 6MWD, m | −0.05 ± 0.02 (.01) | −0.02 ± 0.02 (.15) | −0.05 ± 0.02 (.008) | −0.04 ± 0.01 (.003) | |
| 0.612 | 0.789 | 0.716 | 0.776 | ||
| Log(VEGF-D) | 4.85 ± 2.51 (.06) | 1.63 ± 1.70 (.34) | 3.86 ± 1.89 (.04) | 3.27 ± 1.51 (.03) | |
| 0.636 | 0.825 | 0.763 | 0.815 |
Values are mixed-effects model parameter estimate ± SE (P value). In the Longitudinal section of the table, the value below the P value is the lowest of the estimated within-patient correlations from the model. See Table 1 for expansion of abbreviations.