Table 5.

—SGRQ Change Scores for Subjects Stratified Into Quartiles Based on Change From Baseline to 12 Months in Anchor Values

Anchor	Symptoms	P Value	Activity	P Value	Impacts	P Value	Total	P Value
FEV1		.01		.006		.16		.01
≤ −11.2% (Q1)	−0.12 ± 14.6	.017	−1.71 ± 8.76	.06	0.95 ± 12.1	.025	−0.13 ± 7.98	.006
−11.2% to −3.4% (Q2)	1.45 ± 13.1	.015	1.31 ± 9.84	.004	−0.34 ± 9.96	.17	0.34 ± 8.16	.01
−3.4% to 4.4% (Q3)	4.57 ± 21.4	.002	3.26 ± 8.43	.001	−2.30 ± 13.1	.24	0.66 ± 10.0	.007
> 4.4% (Q4)	−13.4 ± 14.6	Ref	−6.46 ± 8.20	Ref	−6.25 ± 12.8	Ref	−7.53 ± 10.0	Ref
Dlco		.6		.5		.6		.6
≤ −9.9% (Q1)	−3.74 ± 15.2	.736	0.65 ± 8.57	.418	−1.83 ± 13.1	.363	−1.29 ± 8.42	.388
−9.9% to −4.7% (Q2)	2.27 ± 18.5	.193	0.06 ± 8.28	.559	−2.06 ± 10.1	.582	−0.82 ± 8.58	.402
−4.7% to 4.7% (Q3)	−1.02 ± 15.9	.438	−3.14 ± 9.75	.522	−3.15 ± 11.7	.687	−2.92 ± 9.98	.789
> 4.7% (Q4)	−4.60 ± 20.1	Ref	−1.04 ± 11.1	Ref	−2.20 ± 13.9	Ref	−2.07 ± 11.8	Ref
6MWD		.7		.02		.17		.04
≤ −2.3% (Q1)	−1.03 ± 17.9	.400	2.87 ± 7.73	.05	1.81 ± 11.9	.233	2.02 ± 9.18	.06
−2.3% to 4.5% (Q2)	2.54 ± 22.7	.241	0.97 ± 6.53	.37	−0.75 ± 9.35	.662	0.34 ± 7.99	.36
4.5% to 17.1% (Q3)	−3.32 ± 14.5	.449	−5.41 ± 10.8	.26	−6.56 ± 14.8	.301	−5.88 ± 10.2	.33
> 17.1% (Q4)	−5.53 ± 11.9	Ref	−2.22 ± 10.7	Ref	−2.60 ± 11.4	Ref	−2.88 ± 9.41	Ref
Log(VEGF-D)		.04		.8		.5		.16
≤ −9.0% (Q1)	−7.54 ± 15.3	.7	−2.22 ± 8.43	.602	−5.97 ± 16.1	.452	−5.17 ± 11.6	.437
−9.0% to −3.7% (Q2)	−2.70 ± 18.4	.4	−2.48 ± 9.75	.859	−0.78 ± 11.6	.628	−1.51 ± 10.1	.440
−3.7% to 0.8% (Q3)	6.29 ± 17.9	.02	1.43 ± 9.65	.625	2.76 ± 11.5	.505	2.95 ± 9.03	.158
> 0.8% (Q4)	−4.88 ± 12.8	Ref	0.14 ± 10.8	Ref	−3.27 ± 8.49	Ref	−2.44 ± 5.86	Ref

Values are mean ± SD. Boldface numbers are P values for comparison across SGRQ means within anchor; other P values correspond to pairwise comparisons of SGRQ means with anchor using Q4 as the reference. See Table 1 legend for expansion of abbreviations.