Figure 1.

Increased glucose uptake in the lung in idiopathic pulmonary fibrosis. A, CT scan showing increased uptake in the areas of honeycombing and fibrosis. B, Axial attenuation corrected [¹⁸F]-2-fluoro-2-deoxyglucose PET scan showing increased uptake in the areas of honeycombing and fibrosis. C, Hematoxylin and eosin (H&E) staining of a lung biopsy tissue section from the same patient shows a fibroblastic focus (magnification × 20, size bar 20 μm). D, H&E staining of a lung biopsy tissue section from the same patient shows areas of honeycombing (magnification × 10, size bar 100 μm). E, Immunofluorescence staining of paraffin-embedded sections of the same biopsy presented as a merged image of glucose transporter-1 (Glut-1; green) and 4,6-diamidino-2-phenylindole-2-HCl (blue) of an area of honeycombing shows Glut-1 staining associated with erythrocytes. F, High-power magnification of selected area in E (*).