| Total (n = 3,875) |
Event (rates)* |
HR (95% CI)† |
p Value‡ | ||
|---|---|---|---|---|---|
| Women | Men | Women | Men | ||
| Incident coronary heart disease (n = 699/2,416 for women, n = 563/1,459 for men) |
|||||
| Novacode 5 for ischemia§ | |||||
| 5.5/5.6 | 103 (45%) | 63 (46%) | 1.98 (1.55–2.53) | 1.36 (1.01–1.85) | 0.0738 |
| 5.7 | 48 (32%) | 46 (38%) | 1.32 (0.95–1.84) | 1.04 (0.75–1.44) | |
| 5.8 | 226 (33%) | 139 (46%) | 1.39 (1.15–1.67) | 1.40 (1.12–1.73) | |
| 5.0 | 322 (24%) | 315 (35%) | reference | reference | |
| Combined Minnesota Code for ischemia§ | |||||
| C.5/5.6 | 94 (44%) | 52 (50%) | 1.83 (1.43–2.34) | 1.62 (1.18–2.24) | 0.7447 |
| C.7 | 41 (29%) | 46 (41%) | 1.21 (0.86–1.70) | 1.23 (0.88–1.72) | |
| C.8 | 148 (37%) | 95 (44%) | 1.51 (1.23–1.86) | 1.62 (1.27–2.07) | |
| C.0 | 416 (25%) | 370 (36%) | reference | reference | |
| Coronary heart disease death (n = 255/2,416 for women, n = 236/1,459 for men) |
|||||
| Novacode 5 for ischemia | |||||
| 5.5/5.6 | 36 (16%) | 28 (20%) | 1.42 (0.92–2.18) | 1.31 (0.82–2.10) | 0.8110 |
| 5.7 | 21 (14%) | 20 (17%) | 1.35 (0.81–2.25) | 1.04 (0.62–1.73) | |
| 5.8 | 90 (13%) | 63 (21%) | 1.43 (1.06–1.93) | 1.39 (1.00–1.93) | |
| 5.0 | 108 (8%) | 125 (14%) | reference | reference | |
| Combined Minnesota Code for ischemia | |||||
| C.5/5.6 | 35 (16%) | 23 (22%) | 1.43 (0.94–2.18) | 1.52 (0.93–2.49) | 0.9969 |
| C.7 | 16 (11%) | 22 (20%) | 1.06 (0.59–1.89) | 1.17 (0.72–1.91) | |
| C.8 | 63 (16%) | 49 (23%) | 1.67 (1.21–2.29) | 1.85 (1.29–2.65) | |
| C.0 | 141 (8%) | 142 (14%) | reference | reference | |
| Total mortality (n = 1,366/2,416 for women, n = 996/1,459 for men) |
|||||
| Novacode 5 for ischemia | |||||
| 5.5/5.6 | 164 (71%) | 103 (75%) | 1.24 (1.03–1.50) | 1.15 (0.91–1.45) | 0.9847 |
| 5.7 | 87 (59%) | 86 (71%) | 1.01 (0.79–1.28) | 1.00 (0.78–1.28) | |
| 5.8 | 411 (61%) | 233 (77%) | 1.11 (0.98–1.27) | 1.22 (1.04–1.44) | |
| 5.0 | 704 (52%) | 574 (64%) | reference | reference | |
| Combined Minnesota Code for ischemia | |||||
| C.5/5.6 | 153 (71%) | 80 (76%) | 1.26 (1.05–1.52) | 1.19 (0.92–1.54) | 0.2293 |
| C.7 | 87 (61%) | 75 (68%) | 1.14 (0.89–1.45) | 0.90 (0.70–1.17) | |
| C.8 | 256 (64%) | 173 (81%) | 1.21 (1.04–1.40) | 1.42 (1.18–1.71) | |
| C.0 | 870 (52%) | 668 (65%) | reference | reference | |
Event rate is number of events divided by number in that category (percentage) of electrocardiographic myocardial infarction/ischemia by Minnesota Code/Novacode.
Adjusted for key demographic and clinical variables of age, race, education, smoking status, alcohol use, diabetes, hypertension, cancer, increased angina, body mass index, systolic blood pressure, hematocrit, white blood cell count, ankle– brachial index, baseline glucose, insulin, and creatinine.
Assessing equivalence of hazard ratios for men and women.
See Table 1 and Zhang et al8 for ischemia criteria. Nova 5.5/5.6 or Minnesota Code C.5/C.6 as major ST-T change, Nova 5.8 or Minnesota Code C.8 as minor ST-T change, and Nova 5.7 or Minnesota Code C.7 as minor Q change.
Abbreviations as in Table 3.