Fig. 7.

Effects of IL-6 on D2 or D3 activity in MSTO211 and MCF-7 cells, respectively: a IL-6 inhibits D2-mediated outer ring deiodination of T4 by intact MSTO211 cells despite an increase in total D2 activity in the same cells (c). In contrast, IL-6 increases T3 inactivation by intact MCF-7 cells (b) as expected from the increase in total D3 activity in the same cells (d). Both D2 and D3 mRNA were increased by IL-6 through a MAPK-dependent process (data not shown). From Wajner et al. [23]. * p < 0.05 for difference from control.