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. 2013 May 21;2(6):455–463. doi: 10.5966/sctm.2012-0184

Figure 2.

Figure 2.

BM-MSCs and AT-MSCs both differentiate toward the osteogenic and adipogenic lineages. Confluent cultures of BM-MSCs (A–C) and AT-MSCs (D–F) were maintained in osteogenic differentiation medium (A, D), adipogenic differentiation medium (B, E), or control medium (C, F). After 3 weeks of culture in differentiation medium, both BM-MSCs and AT-MSCs were positive for alkaline phosphatase activity (A, D) and lipid droplets were formed (B, E). Control cultures in proliferation medium did not show alkaline phosphatase activity or the formation of lipid droplets. Multipotent stromal cell populations from six BM-MSC donors and from eight AT-MSC donors were tested for their differentiation capacity; representative pictures are shown for BM-MSCs and AT-MSCs. Scale bar = 50 μm. Abbreviations: Adipo, adipogenic; AT-MSC, adipose tissue-derived multipotent stromal cells; BM-MSC, bone marrow-derived multipotent stromal cells; Osteo, osteogenic.