. Author manuscript; available in PMC: 2013 Jun 5.

Published in final edited form as: Int J Obes (Lond). 2010 Oct;34(0 1):S47–S55. doi: 10.1038/ijo.2010.184

Table 1.

Changes in energy expenditure, autonomic nervous system function, and neuroendocrine function in subjects maintaining a reduced body weight with or without leptin “replacement” ^{1, 97, 99}

	Effects of 10% Reduced Weight Maintenance	Effects of Leptin Administration to Weight-Reduced Subjects
Energy Expenditure
Twenty-four-hour energy expenditure	Decreased (−15%)	Reversed
Resting energy expenditure	Decreased or unchanged	No significant change
Thermic effect of feeding	Unchanged	Unchanged
Non-resting energy expenditure	Decreased (−30%)	Reversed
Skeletal muscle work efficiency	Increased (20%)	Reversed
Autonomic Function
Sympathetic Nervous System tone	Decreased (−40%)	Reversed
Parasympathetic Nervous System tone	Increased (80%)	Unchanged
Neuroendocrine Function
Thyroid stimulating hormone	Decreased (−18%)	Unchanged
Triiodothyronine	Decreased (−7%)	Reversed
Thyroxine	Decreased (−9%)	Reversed
Gonadotropins	Decreased	Reversed
Circulating Leptin	Decreased (proportional to fat mass)	Reversed