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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Lancet Oncol. 2013 Feb;14(2):e70–e78. doi: 10.1016/S1470-2045(12)70530-2

Figure 2. Targeting developmental pathways in children.

Figure 2

Some genes that drive cancer are normally active only in specific stages of development (blue triangle). Thus targeting one of these developmental oncogenes in young children (red) may also impair a developmental pathway, in this example linear growth. However, if targeted later in life (black), this adverse effect will not occur.