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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Eur J Haematol. 2012 Nov 22;90(1):16–24. doi: 10.1111/ejh.12021

Table 3.

(A) Complete Responder profiles, (B) Good Partial Responder profiles, (C) Suboptimal Responder profiles

Age/
Sex		 Disease
phenotype		 Length
of Dx
(in months)		 Indication for treatment
with eculizumab		 Pre-tx Hb
(g/dL)		 Post-tx
Hb (g/dL)		 Pre-tx
LDH
(U/L)		 Post-tx
LDH
(U/L)		 Pre-tx
Retic
(K/cu mm)		 Post-tx
Retic
(K/cu mm)		 Pre-tx RBC
clone size
(%)		 Post-tx
RBC
clone
size (%)		 Pre-tx
Gran
clone
size (%)		 Post-tx Gran
clone size
(%)
(A)
33 M Classical   13 Anemia from hemolysis   8.6 17.4 1670   274  NA 133.5 46     6.9 87   24
31 M AA/PNH   82 Thrombosis, anemia from hemolysis   7.4 15.6   771   311   82.6 150.7 73   11.9 99   99
28 M Classical     4 Thrombosis, anemia from hemolysis 10.1 16.2   888   261 110 109.7 51   14 98   99
36 M Classical 192 PNH sx, Thrombosis, anemia from hemolysis   8.4 15.9 3490   135 324.3 101.1 63     6 99   23
(B)
27 M Classical     2 Anemia from hemolysis, PNH sx   8.9 12.7 6218   329 180 164.6 6.66   49 73   87
35 F Classical   84 Anemia from hemolysis, PNH sx   6.6 10.3       H   196   20  NA 54  NA 99  NA
56 F AA/PNH 288 Anemia from hemolysis, PNH sx   8.4   8.9 2042   223 101.5   79.5 25   44 85   96
21 M Classical   60 Anemia from hemolysis, PNH sx   9.6 12 1969   279 208.9 162.3 64  NA 96  NA
31 M Classical 168 Thrombosis, anemia from hemolysis 11 12.81 1591   209 129.2 129.8 83 100 99   99
64 F Classical 108 Anemia from hemolysis, PNH sx   9.2 11.7 1583   247 161.4   86.5 86   99.7 87   75.9
24 F2 AA/PNH   36 Thrombosis   9.9 14.7   157   168     8.2     0.9   1     0 65     0
32 M Classical   13 Anemia from hemolysis, PNH sx 12.1 12.6 2555   240 299.5 325.1 28  NA 88  NA
22 F Classical 122 Anemia from hemolysis, PNH sx   5.8 10.9   924   195 266.1 179.8 77   94 92   99
18 F Classical   26 Anemia from hemolysis, PNH sx   6.3 10 1760   234 219.8 179.8 13   95 55   99
28 F AA/PNH   12 Anemia from hemolysis, PNH sx 11.1   9.3   529   180   69.2   68 34  NA 72  NA
48 M Classical   36 Anemia from hemolysis, PNH sx   6.8 10.3 2343   317 190.1 160.4 38   68 41   62
47 F Classical     2 Thrombosis, anemia from hemolysis, PNH sx 10 10.9 1440   268 160.9     5.1 43   55 90   91
18 F Classical     4 Anemia from hemolysis   5.1 10.0 1767    NA 169.7   NA 37   66 93   98
48 M Classical 204 Anemia from hemolysis   7.6 10.5 4835   277 451.8 321.8 42   99 97   96
57 M Classical 150 Anemia from hemolysis 11.1 10.1 1537    NA 174  NA 34  NA 90  NA
(C)
77 F AA/PNH     9 Anemia from hemolysis   7.8 11.41 1085   303   68.1 113.9   8     7.91 86   59
40 F AA/PNH   12 Thrombosis   8.2   8.2   622   252 112.2 114.8   9   97 66   97
16 F Classical   24 Thrombosis, anemia from hemolysis   9.2   9.8   282   362 251.1  NA 76  NA 97  NA
28 M Classical     1 Anemia from hemolysis, PNH sx   8.2   7.9 2023 1637  NA  NA 13  NA 71  NA
63 M AA/PNH   36 Anemia from hemolysis, PNH sx   8.5   8.5   417   278   32.6   28   7   4 58   72
35 M AA/PNH     2 Thrombosis, anemia from hemolysis 10   7.6  NA   919  NA   84 80     4.51 75   92
46 F Classical     3 Thrombosis, anemia from hemolysis   8.1   9.1 1551   200 139.7 222.9 32   50 83   94
39 M2 Classical   72 Thrombosis   9.9   8.1       H   185 351.4 340 99   86 99 100
63 M Classical   14 Thrombosis, anemia from hemolysis 10.4 10.91   981   189 142.8 187.3 16   341 78   96
51 F AA/PNH     4 Thrombosis, anemia from hemolysis   9.1 11.71   568   222 151.1 106.3 11     3.2 56   18

PNH, paroxysmal nocturnal hemoglobinuria; H, hemolyzed; NA, not available (for patient with treatment initiated at primary institution but followed elsewhere, only information received at time of analysis).

Values for post-treatment performed after minimum of 6 months from initiation of treatment.

1

Transfused value.

2

S/p bone marrow transplantation.