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. Author manuscript; available in PMC: 2013 Aug 15.
Published in final edited form as: Cancer Res. 2012 Jun 27;72(16):4154–4164. doi: 10.1158/0008-5472.CAN-11-2848

FIGURE 1. Genome-wide RNAi-based screen for synthetic lethal interactions with EGFR inhibition.

FIGURE 1

A) Overview of screen and data analyses. B) Unsupervised hierarchical clustering of mapped sequences from individual samples. C) Mapping of SLuGs onto the Wnt/Tankyrase/β-catenin pathway. The number listed to the side of each component is the average fold-change of the most differentially represented shRNA targeting the indicated gene from gefitinib-treated NSCLC cells relative to untreated.