Table 2. Altered transcripts with a link to apoptosis.
Anti-apoptotic | Pro-apoptotic | ||||||
Pathway | Transcript | HGERT/HG | HG/NG | Pathway | Transcript | HGERT/HG | HG/NG |
AKT/Bad | pik3r1 | 1.03 | Caspase | hip1 | 1.05 | ||
AKT/FRAP1 | ddit4l | 0.97 | Cell cycle | maged1 | 1.01 | ||
BLK | elf2 | 0.99 | 1.01 | Cell cycle/CDK | ccni | 1.01 | |
Caspase | hspe1 | 0.99 | Cell proliferation | pdcd7 | 1.02 | 0.99 | |
Caspase | ifi6 | 1.13 | Cell proliferation | ubn1 | 1.02 | ||
Cell proliferation | furin | 1.02 | DNA repair | rrm2b | 0.98 | ||
DNA repair | actr5 | 1.01 | FOX | foxn3 | 1.01 | 0.99 | |
FOX | foxc1 | 1.01 | FOX | foxp1 | 1.01 | ||
Impedes cyt c release | gsn | 1.03 | HER-2/NEU | casc4 | 0.99 | 1.01 | |
JNK/SAPK | mbip | 0.98 | JNK/SAPK | map4k3 | 0.98 | ||
p38 MAP kinase | stk39 | 0.98 | JNK/SAPK | sos1 | 1.06 | 0.94 | |
P53/XIAP inhibition | notch1 | 1.02 | MYC family | mxd4 | 1.02 | 0.98 | |
RAS | rsu1 | 0.99 | P53/CDK | ccnk | 1.01 | ||
RAS | rhob | 1.02 | 0.97 | P53 | rybp | 1.01 | 0.99 |
RAS | rhoj | 1.02 | P53 | tp53bp2 | 1.01 | ||
RAS | rab3b | 1.07 | P53 | tbrg1 | 1.02 | 0.98 | |
TGFβ | acvr2a | 0.99 | P53 | tp53i11 | 1.02 | 0.98 | |
TGFβ | bmp6 | 1.01 | RAS | rassf2 | 1.01 | 1.03 | |
eng | 1.01 | 0.98 | WNT | hbp1 | 0.99 | ||
atxn3 | 0.99 | dap | 1.01 | ||||
pdcd6 | 0.99 | serinc3 | 1.01 | 0.99 | |||
socs3 | 1.01 | sox4 | 1.01 | 0.99 | |||
txndc5 | 1.03 | lyn | 1.02 | 0.99 |