Table 2. Age, Gleason scores, incidence of metastases at diagnosis and tumour Ki67-IR at diagnosis for the cases divided on the basis of median splits of the tumour nCB1IR and pAkt-IR scores.
| Quadrant: (see Fig 3A) | Group A (bottom left) | Group B (bottom right) | Group C (top left) | Group D (top right) | P value | |
| Age in years | ||||||
| median (range) | 74 (56–88) | 73 (52–87) | 75 (62–92) | 74 (51–95) | 0.79a | |
| {n} | {74} | {52} | {57} | {91} | 0.79a | |
| Number (%b) of cases with: | ||||||
| Gleason score | 4–5 | 24 (32%) | 22 (42%) | 6 (11%) | 5 (5%) | |
| 6 | 24 (32%) | 5 (10%) | 24 (42%) | 12 (13%) | <0.0001c | |
| 7 | 12 (16%) | 9 (17%) | 10 (18%) | 20 (22%) | ||
| 8–10 | 14 (19%) | 16 (31%) | 17 (30%) | 54 (59%) | ||
| Metastases at diagnosis | No | 55 (96%) | 37 (93%) | 36 (86%) | 52 (68%) | <0.0001c |
| Yes | 2 (4%) | 3 (8%) | 6 (14%) | 24 (32%) | ||
| Tumour stage | 1a–1b | 49 (66%) | 28 (54%) | 26 (46%) | 28 (31%) | |
| 2 | 15 (20%) | 16 (31%) | 15 (27%) | 25 (28%) | <0.001c | |
| 3 | 9 (12%) | 6 (12%) | 12 (21%) | 33 (37%) | ||
| 4 | 1 (1%) | 2 (4%) | 3 (5%) | 4 (4%) | ||
| %ca d | ||||||
| median (25–75) | 12.5 (10–62.5) | 20 (10–87.5) | 30 (10–77.5) | 70 (30–90) | <0.0001a | |
| {n} | {74} | {52} | {57} | {91} | ||
| Ki-67 index (%) | ||||||
| median (25–75) | 1.7 (0.4–3.0) | 2.7 (0.9–3.7) | 3.0 (1.4–5.6) | 3.9 (2.3–10) | <0.0001c | |
| {n} | {74} | {51} | {56} | {89} |
“Bottom left”, “Bottom right”, “top left” and “top right” refer to the quadrants shown in Fig. 2A.
a
Kruskal-Wallis test.
b
The % value refers to the % of cases for the pAkt-IR/CB1IR group in question (i.e. vertical numbers add up to 100%).
c
2 test.
d
percentage of the specimen that contained tumour. “median (25–75)” refers to the median values, with the 25–75th quartiles given in brackets.