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. 2013 Jun 5;8(6):e65389. doi: 10.1371/journal.pone.0065389

Figure 6. ALA does not affect IOP in DBA mice.

Figure 6

A. Intervention Study: Treatment with ALA began at 6 months of age and continued for four months. Non-treated control (solid circles; n = 30) and ALA treated (open circles; n = 29) DBA/2J mice had similar average IOPs before and during treatment. B. Prevention study: Treatment with ALA began at weaning, 21 days, and continued until mice were 12 months of age. IOP was measured once per month beginning at 2 months. Control (n = 96) and ALA (n = 96) treated DBA/2J mice had similar average IOPs throughout treatment. C. For the prevention experiment, IOP exposure, expressed as mmHg-Days, was calculated by multiplying the measured IOP by the number of days at that IOP and then summing the values. There was no difference in IOP exposure between control and ALA treatments within the low or high IOP category, but the average difference across low and high IOP categories (≥600 mmHg-Days) is significant (*p = 0.001). All mRNA and protein analysis for the prevention experiment was done by IOP level in the control and ALA treatment groups, but was only presented by IOP level when the results were statistically different.