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. 2013 Jun 5;8(6):e65021. doi: 10.1371/journal.pone.0065021

Figure 3. BTBR mice exhibit a varied seizure phenotype.

Figure 3

(A) In response to 6 Hz electroconvulsive shocks, BTBR mice had a significantly reduced threshold compared to control mice, and this reduction was unaffected by KD feeding. *p<0.05 compared to control; n = 16 CD group, n = 8 KD group. (B) BTBR mice did not differ from control mice in latency to tonic/clonic seizures during flurothyl exposure; n = 7–8. (C) Peak seizure intensity was not different between BTBR and control mice in response to PTZ injection; n = 10–12. (D) Latency to first seizure after injection of the dopamine agonist SKF83822 was reduced in BTBRs, but the number of seizures did not differ. **p<0.01 compared to controls; n = 9–13.