Figure 2. C/EBPβ WT and mutants differentially regulate key myeloid genes.

RNA counts for pro-inflammatory M1, anti-inflammatory M2 and other key monocyte/macrophage genes evaluated on CD11b⁺ reprogrammed C/EBPβ ^−/− B cell progenitors. Data were calculated as log₂ and subjected to hierarchical clustering. Results represent expression profiles from three independent experiments. On the right, comparison to data obtained from reprogramming of pre-B cell line by C/EBPα is presented (Bussmann et al., 2009). MPh - WT bone marrow-derived macrophages.