Table 3.

MNI coordinates for the peak of activity in regions activated for No-Go false alarms compared to implicit baseline in FHN and FHP individuals after administration of memantine or placebo

Region (BA)	Left hemisphere	FHN—effect of memantine	FHP—effect of memantine	Right hemisphere	FHN—effect of memantine	FHP—effect of memantine
Superior frontal gyrus (10/9)	−30, 48, 18	↓		27, 54, 18
Supplementary motor area (6/8)	−3, 15, 51	↓		3, 15, 51	↓
Middle frontal gyrus (10)	−33, 39, 18	↓		39, 42, 15
Inferior frontal gyrus (47)	−39, 18, −6			39, 18, −6
Anterior cingulate (32)	−6, 27, 33	↓		6, 30, 27
Precentral gyrus (6)	−42, −15, 51			24, −18, 57
Insula	−42, 9, −9		↓	39, 15, 0
Thalamus	−12, −15, 0			12, −6, −3
Putamen	−18, 12, 3		↓	18, 6, 3		↓
Caudate	−15, 9, 12		↓	15, 9, 3		↓
Subthalamic nucleus	−9, −15, −6			12, −15, −6
Parahippocampal gyrus	−9, −33, −3			12, −33, −3
Superior parietal lobule (7)	−30, −57, 54	↓		27, −66, 51	↓
Precuneus (7)	−6, −51, 51		↓	15, −66, 54	↓
Inferior parietal lobule (40)	−63, −42, 21			60, −51, 27
Posterior cingulate (30)	−21, −69, 3	↓		0, −24, 27		↓
Superior temporal gyrus (42/22/38)	−45, 12, −15,			45, 12, −15	↓	↓
Middle temporal gyrus (21/39)	−57, −27, −9			60, −27, −12
Inferior temporal gyrus (37)	−51, −72−6	↓		54,−72, −6
Fusiform gyrus (37)	−42, −48, −21	↓		42, −54, −24
Lingual gyrus (18)	−12, −72, 0	↓		18, −66, 0
Cuneus (18)	−12, −75, 9			18, −69, 6
Culmen	−30, −57, −30			30, −57, −30	↓
Cerebellum crus 1	−42, −57, −27			42, −57, −27
Tonsil	−36, −57, −45			36, −57, −42	↓
Vermis	−3, −69, −9	↓		3, −9, −15

Regions activated for No-Go correct rejects >baseline across groups during placebo. Only variables showing significant experimental effects are shown, thus FHP vs. FHN placebo for both hemispheres is not shown. A downward arrow represents a reduction in activity during memantine challenge vs. placebo, an upward arrow represents an increased in activity during memantine challenge vs. placebo