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. 2013 Jan 1;9(1):22–28. doi: 10.4161/org.24329

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Figure 3. EphrinB2 GAMs have the potential to exert a pro-anabolic, anti-catabolic effect on bone formation. EphrinB2 overexpression stands to enhance bone formation by two mechanisms, first by increasing osteoblast differentiation and second by blocking osteoclast differentiation.