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Figure 2. Schematic representation of Spp1. The positions of the PHD and the Mer2 interacting domain of Spp1 are based on.37,55 Deletion of the CxxC (C263GYC266) motif was shown to affect Spp1-Mer2 interaction. Coiled-coil regions are indicated above the scheme.55 The regions of Spp1 responsible for its interaction with Set1 and the Swd1-Swd3 module are unknown.
