Table 1. List of chromosome 3 NotI-sites with methylation/deletion frequencies more than 20% in cervical cancer.
| n/n | Gene* | NotI-site** | Locus | Methylation/deletion frequency, % |
||
|---|---|---|---|---|---|---|
| |
|
|
|
ADC |
SCC |
ADC+SCC |
| 1 |
LRRN1 |
NL6-FJ5R (C) |
3p26.2 |
11 (1/9) |
51 (20/39) |
44 (21/48) |
| 2 |
PRICKLE2 |
NR1-NJ9R (C) |
3p14.1 |
22 (2/9) |
49 (19/39) |
44 (21/48) |
| 3 |
ITGA9 |
NL1A401R (D) |
3p21.3 |
33 (3/9) |
44 (17/39) |
42 (20/48) |
| 4 |
LRRC3B |
NL3-CA11RS |
3p24 |
44 (4/9) |
39 (15/39) |
40 (19/48) |
| 5 |
NKIRAS1 |
NL1-CJ4R (C) |
3p24.2 |
22 (2/9) |
41 (16/39) |
38 (18/48) |
| 6 |
RPL15 |
NL1-CJ4R (C) |
3p24.2 |
22 (2/9) |
41 (16/39) |
38 (18/48) |
| 7 |
VHL |
NRLA404R (U) |
3p25.3 |
11 (1/9) |
41 (16/39) |
35 (17/48) |
| 8 |
PDZRN3 |
NL6-AF21R (C) |
3p13 |
33 (3/9) |
33 (13/39) |
33 (16/48) |
| 9 |
IQSEC1 |
NR1-XM13 (C) HSJ4-AB7R (C) |
3p25.2 |
33 (3/9) 0 (0/9) |
31 (12/39) 26 (10/39) |
31 (15/48) 21 (10/48) |
| 10 |
RBSP3 |
NLJ-003RD |
3p21.3 |
11 (1/9) |
36 (14/39) |
31 (15/48) |
| 11 |
GORASP1 |
NL3003R (U) |
3p22-p21.33 |
44 (4/9) |
26 (10/39) |
29 (14/48) |
| 12 |
TTC21A |
NL3003R (U) |
3p22-p21.33 |
44 (4/9) |
26 (10/39) |
29 (14/48) |
| 13 |
FOXP1 |
NL1-BA6R |
3p14.1 |
22 (2/9) |
31 (12/39) |
29 (14/48) |
| 14 |
BHLHE40 |
NR5-IH18RS |
3p26.1 |
11 (1/9) |
31 (12/39) |
27 (13/48) |
| 15 |
CGGBP1 |
NR1-WE11RS |
3p12-p11.1 |
11 (1/9) |
31 (12/39) |
27 (13/48) |
| 16 |
EPHB1 |
NL1A079R (D) |
3q21-q23 |
11 (1/9) |
31 (12/39) |
27 (13/48) |
| 17 |
FGF12 |
NR1-NH1R (C) |
3q28 |
22 (2/9) |
28 (11/39) |
27 (13/48) |
| 18 |
PLCL2 |
NL4-AP18R (C) |
3p24.3 |
0 (0/9) |
31 (12/39) |
25 (12/48) |
| 19 |
ABHD5 |
NR1-AN24RS |
3p21 |
33 (3/9) |
23 (9/39) |
25 (12/48) |
| 20 |
C3orf77 |
NR1-AN24RS |
3p21 |
33 (3/9) |
23 (9/39) |
25 (12/48) |
| 21 |
ZIC4 |
NR1-PD1R |
3q24 |
22 (2/9) |
26 (10/39) |
25 (12/48) |
| 22 |
WNT7A |
NL4-BK12R (C) |
3p25 |
0 (0/9) |
28 (11/39) |
23 (11/48) |
| 23 |
UBE2E2 |
NR1-WF18R (C) |
3p24.2 |
11 (1/9) |
26 (10/39) |
23 (11/48) |
| 24 |
THRB |
NL4-BB6R (C) |
3p24.2 |
22 (2/9) |
23 (9/39) |
23 (11/48) |
| 25 |
ALDH1L1 |
NL4-BC8R (C) |
3q21.3 |
11 (1/9) |
26 (10/39) |
23 (11/48) |
| 26 |
RPL32 |
HSJ4-AB7R (C) |
3p25.2 |
0 (0/9) |
26 (10/39) |
21 (10/48) |
| 27 |
LOC285375 |
NR1-PL22R (C) |
3p25.1 |
11 (1/9) |
23 (9/39) |
21 (10/48) |
| 28 |
FGD5 |
NL4-DP2RS |
3p25.1 |
11 (1/9) |
23 (9/39) |
21 (10/48) |
| 29 |
PPP2R3A |
NL1-FK10R (C) |
3q22.1 |
0 (0/9) |
26 (10/39) |
21 (10/48) |
| 30 | SOX14 | NR1-WJ2RS | 3q22-q23 | 0 (0/9) |
26 (10/39) |
21 (10/48) |
*
Four pairs of adjacent genes have one common NotI-site (5 and 6, 11 and 12, 19 and 20, 9 and 26), IQSEC1 gene has two NotI-sites, **sequences available at www.ncbi.nlm.nih.gov/nuccore/.