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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Cancer Res. 2013 Apr 11;73(11):3248–3261. doi: 10.1158/0008-5472.CAN-12-1578

Figure 3. Double mutant KRAS and PIK3CA cells form tumors in athymic nude mice.

Figure 3

A, DKI cells or B, MDA-MB-231 (positive control) cells were inoculated and grown as xenografts in nude mice as described in Materials and Methods. Results are average tumor volumes from five mice in each group and represent three independent experiments.

C, Histology of DKI tumor xenograft tissue in nude mice. Tumor xenografts were harvested 4 weeks post inoculation. Representative tumor xenograft slides were stained with hematoxylin and eosin. Magnifications: 100x in top row, 400x in bottom row. All DKI tumor xenografts show increased cell proliferation and lymphocyte invasion.