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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Cancer Res. 2013 Apr 10;73(11):3381–3392. doi: 10.1158/0008-5472.CAN-12-4047

Figure 7. Combination treatment of human HNSCC xenografts with cetuximab and IPI-926 blocks tumor re-growth.

Figure 7

A. Growth kinetics of 6 HNSCC xenograft cases treated with cetuximab, IPI-926 and cetuximab+IPI-926. B. Tumor/Control values for treated cases. C. Staining of E-cadherin (green) and Keratin-14 (red) in HNSCC xenografts after treatment. Treatment with IPI-926 decreased E-cadherin, pushing cells into an EGFR-driven EMT-like state. Scaling bars represent 50μm at 40×. *P<0.05.