Figure 2.
Effect of ANG II on STAT3 activation and expression of protective proteins. WT and SA/SA mice were treated with saline or ANG II for 17 days. Ventricles of the heart were processed for Western analysis. (A) Activation of STAT3. Homogenates containing equal protein levels were probed for STAT3 S727 and Y705 phosphorylation and total STAT3. (B) Ventricles were assayed for expresion SOD2 and Bcl-xL. GAPDH was probed for to ensure equal loading. Each lane represents an individual mouse heart.