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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Hypertens Res. 2013 Jan 31;36(6):496–503. doi: 10.1038/hr.2012.223

Figure 4.

Figure 4

Hypertension-induced cardiac collagen. (A) Trichrome staining of myocardium. Panel A, WT+Saline: Typical cross-sectional morphology of myocardium in the left ventricle of WT mice. Panel B, SA/SA+Saline: Typical cross-sectional morphology of myocardium in left ventricle of SA/SA mice. Panel C, WT+ANG II: An increase in collagen (blue stain) is seen as small foci of fibrosis scattered in the left ventricular myocardium. Panel D, SA/SA+ANG II: The collagen fibrosis comprises larger regions and appears more extensive in SA/SA left ventricular myocardium. Scale bar = 50 μm. Bar Graph: Percent change in collagen among WT and SA/SA mice treated with saline or ANG II. *P < 0.05 SA/SA+ANG II and WT+ANG II vs. both saline controls; Kruskal-Wallis ANOVA followed by Dunn’s post hoc test.