Table 1.
Expression of CYP enzymes involved in steroid biosynthesis and the major steroid products in classical steroidogenic tissues.
| Organ/tissue | CYP enzymes | Other Steroidogenic proteins | Major Steroid products |
|---|---|---|---|
| Adrenal cortex, zona glomerulosa | 11A1, 17A1, 21A2, 11B2 | StAR protein, 3βHSD2 | aldosterone |
| Adrenal cortex, zona fasciculata | 11A1, 17A1, 21A2, 11B1 | StAR protein, 3βHSD2 | cortisol |
| Adrenal cortex, zona reticularis | 11A1, 17A1, 11B1 | StAR protein, cytochrome b5, sulfotransferase | DHEA-S |
| Ovary, corpus luteum | 11A1, 17A1, 19A1 | StAR protein, 3βHSD2, | progesterone, |
| Ovary, follicle, granulosa cells | 11A1, 19A1 | StAR protein, 17βHSD1 | estradiol |
| Ovary, follicle, thecal cells | 17A1 | 3βHSD2 | androstendione (converted to estrogen in granulosa) |
| Testis, leydig cells | 11A1, 17A1, | StAR protein, 3βHSD2, 17βHSD3 | testosterone |
| Placenta, syncytiotrophoblasts | 11A1, 19A1 | MLN64, 3βHSD1, 17βHSD1, steroid sulfatase | progesterone, estradiol, estrone, estriol |
See [23] for further details of steroidogenesis in the tissues listed.