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. Author manuscript; available in PMC: 2013 Aug 14.
Published in final edited form as: Am J Geriatr Psychiatry. 2013 Feb 6;21(8):10.1016/j.jagp.2012.11.013. doi: 10.1016/j.jagp.2012.11.013

Table 3.

Effects of Covariate Adjustment on Personality Estimates

Covariates Tested to Explain Personality Effects

Predictor HDRS Affective Alcohol/Substance Smoking Hyper-Tension Fasting Cholesterol
Fixed Effects
Neuroticism 0.59*** (0.17) 0.62*** (0.16) 0.62*** (0.16) 0.61*** (0.16) 0.50*** (0.17)
Extraversion −0.15 (0.16) −0.17 (0.17) −0.16 (0.16) −0.21 (0.16) −0.21 (0.17)
Openness −0.07 (0.18) −0.07 (0.18) −0.06 (0.18) −0.09 (0.18) 0.01 (0.19)
Agreeableness −0.23 (0.18) −0.19 (0.18) −0.43 (0.18) −0.19 (0.18) −0.31 (0.18)
Conscientiousness −0.43** (0.16) −0.43** (0.16) −0.43** (0.16) −0.42** (0.16) −0.49** (0.16)
Time: Years 1.28*** (0.06) 1.25*** (0.07) 1.33*** (0.09) 1.34*** (0.10) 1.35*** (0.08)
Time: Years 2 −0.11* (0.05) −0.11* (0.05) −0.11* (0.05) −0.11* (0.05) −0.11* (0.05)
Time: Years 3 0.06 (0.03) 0.06* (0.03) 0.06* (0.03) 0.06* (0.03) 0.06 (0.03)
Baseline Age (Years) 0.13*** (0.02) 0.13*** (0.02) 0.13*** (0.02) 0.12*** (0.02) 0.12*** (0.02)
Education (Years) −0.07 (0.06) −0.07 (0.06) −0.07 (0.06) −0.05 (0.06) −0.09 (0.06)
Female Gender −0.49 (0.28) −0.42 (0.29) −0.49 (0.28) −0.48 (0.28) −0.47 (0.28)
Agreeableness* Time −0.18** (0.07) −0.16* (0.07) −0.19** (0.05) −0.19** (0.05) −0.17* (0.07)
HDRS Affective (Time varying) 0.09 (0.07)
HDRS Affective* Time 0.03 (0.06)
History of Alcohol/Substance Abuse/Dependence 0.42 (0.33)
History of Alcohol/Substance Abuse/Dependence* Time 0.15 (0.11)
Current Smoker −.13 (0.51)
Current Smoker* Time −0.16 (0.19)
Former Smoker −0.01 (0.27)
Former Smoker* Time −0.08 (0.10)
History of Hypertension 1.02*** (0.28)
History of Hypertension* Time −0.08 (0.11)
Fasting Cholesterol (Time Varying) −0.00 (0.00)
Fasting Cholesterol* Time −0.00 (0.00)
Intercept (Average CIRS at Year 3) 9.59*** (0.25) 9.59*** (0.25) 9.73*** (0.28) 9.00*** (0.30) 9.70*** (0.23)

Random Effects
Linear Time Variance 0.50*** (0.06) 0.50*** (0.06) −0.51*** (0.07) −0.50*** (0.07) 0.50*** (0.08)

Quadratic Time Variance .08*** (0.02) .08*** (0.02) .08*** (0.03) .08*** (0.03) .08*** (0.03)

Cubic Time Variance .05*** (0.02) −.05*** (0.02) .05*** (0.02) .05*** (0.02) .05*** (0.02)

Intercept Variance 7.11*** (0.49) 7.11*** (0.49) 7.10*** (0.49) 6.89*** (0.48) 6.95*** (0.48)

Residual Variance .59*** (0.06) .59*** (0.06) .59*** (0.49) 0.59*** (0.06) .60*** (0.06)

N 1453 1453 1453 1453 1414
AIC 5710 5709 5715 5697 4856
BIC 5816 5815 5831 5803 4958

Notes. Entries are parameter estimates (change in CIRS scores per unit increase in predictor), beneath which standard errors are in parentheses. HDRS = Hamilton Depression Rating Scale. Personality traits and HDRS affective scores scaled by interquartile range, so that 1 unit corresponds to difference between a person at 75th v. 25th percentile.

*

p ≤ .05

**

p ≤ .01

***

p ≤ .001.

P-values are from z-statistics.