Table 3.
Failure rate of keratoprosthesis by surgical indication with comparison testing of time-to-failure data.
| Etiology | Failure (n=21) | Retention (n=279) | ||
|---|---|---|---|---|
| rate (%) |
n | n | p-value* | |
| Autoimmune | 29.0 | 9 | 22 | <0.0001 |
| Chemical Injury | 3.2 | 1 | 30 | 0.508 |
| Herpes Simplex Virus | 4.8 | 1 | 20 | 0.790 |
| Fuchs Dystrophy | 12.5 | 1 | 7 | 0.621 |
| Keratoconus | 9.1 | 1 | 10 | 0.969 |
| Infectious Keratitis | 5.3 | 1 | 18 | 0.643 |
| Neurotrophic Keratitis | 0 | 0 | 4 | 0.617 |
| Limbal Stem Cell Deficiency | 0 | 0 | 9 | 0.440 |
| Pseudophakic Bullous Keratopathy | 1.8 | 1 | 54 | 0.064 |
| Trauma | 15.4 | 2 | 11 | 0.520 |
| Aniridia | 14.3 | 1 | 6 | 0.566 |
| Miscellaneous | 8.6 | 3 | 32 | 0.889 |
| Failed Graft | 0 | 0 | 50 | 0.098 |
| Unknown | 0 | 0 | 6 | 0.390 |
log-rank test
For eyes classified as miscellaneous, underlying diagnoses leading to corneal replacement surgery included visually significant corneal scar (6), uveitis (3), thermal burn (2), Darier’s diseae (1), Alport’s syndrome (1), Salzmann’s nodular degeneration (2), Alpert’s syndrome (1) Wegener’s granulomatosis (1), atopic keratoconjuctivitis (1), gelatinous drop-like dystrophy (1), retinoblastoma (1), Herpes zoster virus (1), rheumatoid arthritis (1), ocular surface tumor (1), syphilitic keratitis (1), vernal keratoconjunctivitis (1), Goldenhaar’s syndrome (1), Mooren’s ulcer (1), congenital hereditary endothelial dystrophy (1), congenital rubella (1), graft versus host disease (1), rosacea (1), measles keratitis (1), trachoma (1), congenital alacrima (1), and anterior segment dysgenesis (1).