Table 1.
CD39 and CD73 in solid and blood neoplasm.
| Cancer types | CD39/CD73 Expression and Activity | Refs |
|---|---|---|
|
| ||
| Solid Neoplasia | ||
|
| ||
| Glioma | Increased CD73 mRNA | [161] |
|
| ||
| Head Neck | Increased CD39 and CD73 expression and activity in Treg cells | [162] |
|
| ||
| Melanoma | Increased CD73 expression is associated with a highly invasive phenotype of melanoma | [156] |
| Increased CD39 expression is related to the differentiation of melanocytes into malignant cells | [163] | |
|
| ||
| Thyroid | Increased CD73 expression and activity in papillary carcinoma | [164] |
|
| ||
| Breast | Increased CD73 mRNA and protein level and increased enzyme activity | [151] |
| Involvement of CD73 in tumor growth and the suitability of this enzyme as a marker of breast cancer progression | [165] | |
| CD73 expression correlates positively with epidermal growth factor receptor expression/function | [166] | |
|
| ||
| Pancreas | Increased CD39 mRNA | [153] |
|
| ||
| Liver | CD39 expression on Tregs facilitates hepatic growth of metastatic melanoma | [152] |
|
| ||
| Colon | No changes in CD39 expression in human | [167] |
| Increased CD73 expression | [168] | |
|
| ||
| Bladder | Increased CD73 expression | [169] |
|
| ||
| Ovarian | Increased CD39 and CD73 expression | [170] |
|
| ||
| Prostate | CD73 activity promotes prostate cancer growth and metastasis | [171] |
|
| ||
| Blood Neoplasia | ||
|
| ||
| Leukemia | Increased CD39 expression and activity on chronic lymphocytic leukemia cells. | [172] |
| Increased CD39 expression on CD4+ T lymphocytes in patients with chronic lymphocytic leukemia. | [173] | |
|
| ||
| Lymphoma | Increased CD39 expression on CD4+ and CD8+ T cells in patients with follicular lymphoma | [174] |