Table 2.
Summary of the behavioral measurements collected during PTSA procedure of the animals exposed to clomipramine or quinpirole chronically and their respective controls. Results are reported as mean ± SEM.
| Behavioral Measures | Controls (RE) | Clomipramine (RE) | Controls (SA) | Clomipramine (SA) |
|---|---|---|---|---|
| Lever-Press Training | ||||
| Completed Trials | 40.0 ± 0.0 | 40.0 ± 0.0 | 40.0 ± 0.0 | 40.0 ± 0.0 |
| Unpressed Trials | 0.3 ± 0.2 | 0.0 ± 0.0 | 0.6 ± 0.2 | 1.0 ± 0.3 |
| Uncompleted Trial | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Extra-lever press - C | 10.7 ± 1.4 | 10.8 ± 2.6 | 19.3 ± 6.3 | 12.7 ± 3.2 |
| Non Rewarded-lever Press | 0.7 ± 0.5 | 1.0 ± 0.3 | 1.1 ± 0.5 | 5.8 ± 2.3 |
| Signal Attenuation | ||||
| Completed Trials | 10.0 ± 1.0 | 8.6 ± 1.1 | ||
| Uncompleted Trial | 20.0 ± 1.0 | 21.4 ± 1.1 | ||
| Test | ||||
| Completed Trials | 24.2 ± 4.0 | 27.0 ± 2.3 | 12.4 ± 1.7a | 13.0 ± 2.4a |
| Unpressed Trials | 20.7 ± 3.1 | 20.0 ± 2.1 | 27.2 ± 1.4a | 29.4 ± 1.8a |
| Uncompleted Trial | 5.2 ± 1.8 | 3.0 ± 0.4 | 10.5 ± 1.7a | 7.6 ± 1.2a |
| Extra-lever press - C | 34.5 ± 6.8 | 42.2 ± 4.4 | 27.7 ± 3.2a | 21.7 ± 4.3a |
| Extra-lever press - U | 29.2 ± 10.1 | 22.5 ± 5.2 | 61.8 ± 10.1a | 43.4 ± 10.3a |
| Non Rewarded-lever Press | 7.7 ± 1.6 | 19.7 ± 5.0c | 18.2 ± 3.5 | 12.0 ± 2.6 |
| Behavioral Measures | Controls (RE) | Quinpirole (RE) | Controls (SA) | Quinpirole (SA) |
|
| ||||
| Lever-Press Training | ||||
| Completed Trials | 40.0 ± 0.0 | 40.0 ± 0.0 | 40.0 ± 0.0 | 40.0 ± 0.0 |
| Unpressed Trials | 0.7 ± 0.3 | 0.6 ± 0.4 | 0.1 ± 0.1 | 0.3 ± 0.2 |
| Uncompleted Trial | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Extra-lever press - C | 23.6 ± 7.2 | 20.4 ± 4.7 | 17.0 ± 2.3 | 23.7 ± 6.6 |
| Non Rewarded-lever Press | 3.7 ± 2.0 | 3.7 ± 1.6 | 3.5 ± 1.9 | 2.0 ± 0.9 |
| Signal Attenuation | ||||
| Completed Trials | 7.7 ± 1.4 | 11.2 ± 2.0 | ||
| Uncompleted Trial | 22.3 ± 1.4 | 18.8 ± 2.0 | ||
| Test | ||||
| Completed Trials | 23.1 ± 2.5 | 36.4 ± 3.5b | 12.5 ± 1.9a | 16.6 ± 3.2a,b |
| Unpressed Trials | 17.9 ± 1.7 | 7.9 ± 2.6b | 26.6 ± 1.9a | 14.2 ± 3.5a,b |
| Uncompleted Trial | 9.0 ± 1.5 | 5.7 ± 1.7b | 10.9 ± 1.2a | 19.2 ± 3.2a,c |
| Extra-lever press - C | 36.5 ± 8.4 | 20.9 ± 5.0b | 23.2 ± 6.1 | 12.4 ± 4.7b |
| Extra-lever press - U | 37.7 ± 4.3 | 9.0 ± 3.7 | 45.6 ± 4.7a | 43.3 ± 16.2a |
| Non Rewarded-lever Press | 11.7 ± 2.2 | 2.0 ± 0.8b | 15.9 ± 3.5 | 2.9 ± 0.9b |
a, b and c indicates significant effect respectively for extinction type, drug treatment and interaction of both (p<0.05).