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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Clin Cancer Res. 2013 Apr 2;19(11):2984–2994. doi: 10.1158/1078-0432.CCR-12-2008

Figure 3.

Figure 3

A. IGF-1 circumvents MEDI-573 inhibition. HUVECs were grown as described in Material and methods then stimulated with VEGF165 in the absence or presence of MEDI-573 (30 μg/ml), or antibody plus IGF-1 (10 ng/ml) or IGF-2 (50 ng/ml). Tube formation was quantified as described in Materials and Methods. Each result is the mean ± SE for 3 independent experiments. B. IGF-2 circumvents MAB391 inhibition. HUVECs were grown Medium 200, then stimulated with VEGF165 in the absence or presence of MAB391 (15 μg/ml), or antibody plus IGF-1 (10 ng/ml) or IGF-2 (50 ng/ml). Tube formation was quantified as described in Materials and Methods. Each result is the mean ± SE for 3 independent experiments.