Table 2.

Nogo receptor family interactions

	ligand	ligand localization in the CNS	function of the interaction in the axonal compartment	function of the interaction in the dendritic compartment	references
NgR1	Nogo66	pre- and postsynaptic, myelin,	growth cone collapse	synaptic strength	[15, 18]
NgR1	MAG	myelin	growth cone collapse		[15, 18]
NgR1	OMgp	pre- and postsynaptic, myelin	growth cone collapse	synaptic strength	[15, 18]
NgR1	NgR1, NgR3	neuron pre- and postsynaptic	?	?	[22]
NgR1	Lingo-1	neuron, pre-synaptic	co-receptor	?	[9]
NgR1	p75, Troy/Taj	neurons, astrocytes	co-receptor	?	[9]
NgR1	GT1b	mostly neuronal	co-receptor	?	[107]
NgR1	APP, Aβ	neurons and glia	decreases Aβ production	?	[102]
NgR1	FGF2, FGF1	ECM/proteoglycans	decreased branching	synaptic strength	[42]
NgR1	BLyS	astrocytes, microglia, macrophages	growth inhibition	?	[108]
NgR1	LGI1	neuronal, excitatory synapses	Nogo66 antagonist	?	[89]
NgR1	ADAM22	postnatal neurons	enhances binding of LGI1	?	[89]
NgR1	MT3-MMP	microglia, ECM	NgR1 shedding	NgR1 shedding?	[91]
NgR1	Crtac1B/ LOTUS	neurons, lateral olfactory tract axons	Nogo66 antagonist, LOT fasciculation	?	[109]
NgR1	CSPGs	ECM, perineuronal nets	inhibition together with NgR3	?	[22]
NgR1	HSPGs	neurons and glia	?	?	[22]
NgR1	Olfactomedin-1	DRG and RGC neurons	NgR1 antagonist	?	[110]
NgR2	MAG	myelin	inhibition when overexpressed in vitro		[4]
NgR2	APP	neurons and glia	enhanced APP processing and Aβ production	?	[103]
NgR3	CSPGs	ECM, perineuronal nets	inhibition together with NgR1	?	[22]
NgR3	HSPGs	ECM	?	?	[22]
NgR3	APP	neurons and glia	APP processing	?	[103]