Table 2.

Phenotypic characteristics and the Nkx2.5 mutation status of the affected pedigree members.

Subject Information				Phenotype	Electrocardiogram		Echocardiogram		Genotype
Identity	Gender	Age at time of study (years)	Age at first diagnosis of AF (years)	AF (classification)	QRS interval (ms)	QT/QTc	LAD (mm)	LVEF (%)	Nkx2.5 mutations
Family 1									N19D
II-1	M	52	45	Long-lasting persistent	98	396/465	38	65	+/–
Family 2									F186S
I-1	M	65a	46	Long-lasting persistent	120	408/427	46	58	N/A
II-1	M	46	32	Persistent	110	388/450	42	65	+/–
II-5	M	40	35	Paroxysmal	104	438/482	40	62	+/–
II-8	F	38	38	Paroxysmal	88	418/424	37	68	+/–
III-2	M	22	22	Paroxysmal	86	382/424	32	64	+/–

Note: AF  =  atrial fibrillation; F  =  female; M  =  male; N/A  =  not available or not applicable; LAD  =  left atrial dimension; LVEF  =  left ventricular ejection fraction; QT  =  QT interval; QTc  =  corrected QT interval. + indicates present and – denotes absent. ^a Age at death.