Figure 2.

Body weight changes of male (A) and female (B) SD rats during the 28-day toxicological assessment. The vehicle, 0.5% CMC (10 ml/kg/day), was administered to rats in the vehicle group. No significant differences were detected between the treated (750, 1250, 2500 mg/kg) and control (vehicle 10 ml/kg) groups. All values are expressed as the mean±S.E.M. (n = 5). Representative microscopic findings (C) for the heart, kidneys, liver, lungs, and spleen of SD rats treated orally with 750, 1250, or 2500 mg/kg MEFL or the vehicle for 28 days.